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Extracellular Matrix (ECM) The structural scaffold of proteins and carbohydrates surrounding cells in connective tissue

Although preclinical findings have been encouraging in several areas, responses can vary significantly between individuals, and treatment decisions should always be based on a comprehensive medical assessment rather than a single therapy

The female mice (homozygous for Hba tm1(HBA)Tow and heterozygous for Hbb tm2(HBG1,HBB*)Tow and Hbb tm3(HBG1,HBB)Tow [h/h:: A / S ], sickle-cell trait mice) and male mice (homozygous for both Hba tm1(HBA)Tow and Hbb tm2(HBG1,HBB*)Tow [h/h:: S / S ], sickle SCD mice) were bred to generate SCD mice

Studies broadened into structural, vascular, and epithelial systems

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PMC 3499978